|
KMID : 1134120170200010045
|
|
Journal of Breast Cancer
2017 Volume.20 No. 1 p.45 ~ p.53
|
|
|
Clinicopathologic and Prognostic Significance of Transducin-Like Enhancer of Split 1 Protein Expression in Invasive Breast Cancer
|
|
Lee Ji-Hye
Bae Sang-Byung
Oh Mee-Hye
Cho Hyun-Deuk
Jang Si-Hyong
Hong Soon-Auck
Cho Jun-Hun
Kim Sung-Yong
Han Sun-Wook
Lee Jong-Eun
Kim Han-Jo
Lee Hyun-Ju
|
|
|
Abstract
|
|
|
Purpose: Transducin-like enhancer of split 1 (TLE1) is a member of the TLE family of transcriptional co-repressors that control the transcription of a wide range of genes. We investigated the prognostic significance of TLE1 protein expression in breast cancers by using immunohistochemistry and explored the relationship of TLE1 with clinicopathological parameters.
Methods: Immunohistochemistry was performed on 456 cases of breast cancer tiled on tissue microarrays. The relationship between TLE1 expression in normal breast specimens and ductal carcinoma in situ (DCIS) was also analyzed.
Results: TLE1 was highly expressed in 57 of 456 (12.5%) carcinoma samples. TLE1 was more frequently expressed in DCIS and invasive breast cancers than in normal breast tissue (p=0.002). High expression of TLE1 significantly correlated with negative lymph node (LN) metastasis (p=0.007), high histologic grade (p<0.001), estrogen receptor negativity (p<0.001), progesterone receptor negativity (p<0.001), human epidermal growth factor receptor 2 (HER2) positivity (p<0.001), and high Ki-67 proliferation index (p<0.001). Based on intrinsic subtypes, high TLE1 expression was strongly associated with HER2+ and triple-negative breast cancers (TNBC) (p<0.001). Survival analysis demonstrated no significant association between TLE1 expression and disease-free survival (DFS) (p=0.167) or overall survival (OS) (p=0.286). In subgroup analyses, no correlation was found between TLE1 expression and DFS or OS according to LN status or intrinsic subtype.
Conclusion: High TLE1 expression is significantly associated with the HER2+ and TNBC subtypes. This is the first study documenting immunohistochemical expression of TLE1 in invasive breast cancer and its association with clinicopathological parameters, prognosis, and intrinsic subtype.
|
|
|
KEYWORD
|
|
|
Breast neoplasms, Immunohistochemistry, Prognosis, TLE1 protein, human
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|